WebJul 1, 2024 · Preclinical studies have shown low to moderate intensity heterogeneous PSMA staining in salivary glands on immunohistochemistry, in addition to low uptake of radiolabeled anti-PSMA antibodies, both of which are incongruent with the high uptake seen on diagnostic PSMA-targeted PET/CT scans [2]. WebSnippet: RATIONALE: Salivary glands are highly perfused and express the prostate-specific membrane antigen (PSMA) receptor as well as the sodium—iodide symporter. As a consequence, treatment with (177)Lu/(225)Ac-PSMA for prostate cancer or (131)I for thyroid cancer leads to a high radiation dose in the salivary glands, and patients can be …
Retrospective analysis of PSMA PET/CT thyroid incidental
WebApr 28, 2015 · The prostate-specific membrane antigen (PSMA) has recently emerged as a target for radionuclide imaging and therapy of prostate cancer, but no study has yet investigated its role in a number of other cancers. The prostate-specific membrane antigen (PSMA) has recently emerged as a target for radionuclide imaging and therapy of … WebMay 3, 2024 · While the exact mechanism of intense PSMA-ligand uptake in salivary glands remains incompletely understood, it is apparent that there are certain nonspecific … order painted car parts
Nonprostatic diseases on PSMA PET imaging: a …
WebIntroduction: Xerostomia is a well-known complication after iodine-131 (131 I) therapy for thyroid carcinoma. It is currently insufficiently understood how the dose and biodistribution of 131 I relates to salivary gland toxicity, and whether this is consistent for all salivary glands within a single patient. Prostate-specific membrane antigen (PSMA) positron emission … WebWithin 2.5 hours of administration, lutetium Lu 177 vipivotide tetraxetan distributes to gastrointestinal tract, liver, lungs, kidneys, heart wall, bone marrow, and salivary glands. Vipivotide tetraxetan and non-radioactive lutetium vipivotide tetraxetan are 60% to 70% bound to human plasma proteins. Elimination. WebJan 15, 2024 · The PSMA PET/CT scans showed focal PSMA uptake in the thyroid gland in 70% of PTI cases (Fig. 3 a). One case also had uptake in cervical lymph nodes (level VI). Laboratory testing including thyroid-stimulating hormone (TSH), T4 levels was performed in 21% of cases and most of them were euthyroid. how to treat ground for hookworms