Witryna15 lip 2024 · While the concept of coordinating bioactive ligands to organoruthenium moieties was introduced in the 1990ies , the strategy has only recently gained real traction in the development of organometallic anticancer agents , , .These efforts have resulted in comprehensive investigations for a variety of ligand systems with their … WitrynaOrganoruthenium-catalyzed chemical protein synthesis to elucidate the functions of epigenetic modifications on heterochromatin factors† Naoki Kamo, a Tomoya Kujirai, …
An Organoruthenium Anticancer Agent Shows Unexpected Target ... - PubMed
Witryna22 mar 2024 · Utilizing the organoruthenium catalyst, heterochromatin factors above 20 kDa, such as linker histone H1.2 and heterochromatin protein 1α (HP1α), bearing site-specific PTMs including phosphorylation, ubiquitination, citrullination, and acetylation have been synthesized. The biochemical assays using synthetic proteins revealed … Witryna20 maj 2024 · We report a new series of organoruthenium(II) complexes bearing structurally modified pyrithione ligands with extended aromatic scaffold, which overcome platinum and adriamycin resistance in human ovarian cancer cells. The mechanism of action of such complexes appears to be unique from that of cisplatin, involving G1 cell … showmax torrent
Transfer Hydrogenation and Antiproliferative Activity of …
Witryna17 cze 2024 · Organoruthenium (II) complexes featuring pyrazole-linked thiosemicarbazone ligands: Synthesis, DNA/BSA interactions, molecular docking, … Witryna31 mar 2024 · Efficient Organoruthenium Catalysts for α-Alkylation of Ketones and Amide with Alcohols: Synthesis of Quinolines via Hydrogen Borrowing Strategy and their Mechanistic Studies Witryna15 sty 2024 · Figure 3 shows the anti-LPO activity of the organoruthenium complexes as compared to BHA as standard. Among organoruthenium complexes studied, the anti-LPO effect in the following order: Cmplx 2 < Cmplx 3 < Cmplx 1 < BHA. Cmplx 1 has the maximum relative total antioxidant activity as compared to Cmplx 2 and Cmplx 3. showmax to dstv explora