Ionophore nigericin
WebNigericin is an antibiotic isolated Streptomyces hygroscopicusthat acts as an H+, K+, Na+, Pb2+ionophore. Similarly to Valinomycin (Prod. No. BML-KC140), Nigericin is most … Web21 dec. 2004 · The selectivity of nigericin for Pb(2+) exceeds that of ionomycin or monensin and arises, at least in part, from a high stability of nigericin-Pb(2+) complexes. Plots of …
Ionophore nigericin
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Web1 dec. 2024 · Other compounds, nigericin, indanomycin, monensin, and lasalocid, showed selectivity of about 50–100 fold. ... Ionophore X-206 found to inhibit viral replication in cell cultures. WebNigericin has been employed to study anion transport (Section 2.5) and to modify the pH gradient across energy-conserving membranes. It is often stated that nigericin abolishes ΔpH across a membrane; in fact, the ionophore equalises the K + and H + concentration gradients, with the final ion gradients depending on the experimental conditions.
WebNigericin is a microbial toxin derived from the Gram-positive bacteria Streptomyces hygroscopicus. It induces the release of IL-1β in response to the activation of the NLRP3 … Web6 okt. 2016 · Ionophores such as valinomycin and nigericin are potent tools for studying the impact of ion perturbance on cellular functions. To obtain a broader picture about molecular components involved in mediating the effects of these drugs on yeast cells under respiratory growth conditions, we performed a screening of the haploid deletion mutant …
WebThe ionophore nigericin equilibrates pH across cells so that the final ion gradients depend on the experimental conditions . Fluorescence intensity was measured in triplicate using the Varioskan LUX Multimode Microplate Reader (Thermo Fisher Scientific) for light emitted at 440 nm and 540 nm with reference excitation wavelengths of 329 nm and 384 nm, … WebThe ionophore nigericin transports Pb2+ with high activity and selectivity: a comparison to monensin and ionomycin. Biochemistry, 2004, 43(50): 15956-15965. [3]. Eytan GD, Carlenor E, Rydström J. Energy-linked transhydrogenase. Effects of valinomycin and nigericin on the ATP-driven transhydrogenase reaction catalyzed by reconstituted ...
WebNigericin sodium salt is a potassium ionophore, exchanges K + for H + across biological membranes, in a similar manner to Valinomycin (Cat. No. 3373). Stimulates mitochondral …
WebToxins 2013, 5 1168 control of serum-response element (SRE). All dermonecrotic toxins carry a glutamine deamidase activity at their C-terminus that activates their G-protein target substrates and use their N-terminus as the machinery for binding to cells and facilitating membrane translocation of their cargo (activity sonic chaos infinite worldWeb15 apr. 2016 · The role of carboxylic ionophores (including nigericin and monensin) in lysosomal protein degradation was shown previously, and interestingly monensin inhibited autophagy (29). Thus, monensin and nigericin produced opposite effects on pH and on autophagy and mitophagy that again, suggests the effect of intracellular pH on … sonic chao resort islandWebNigericin acts as an H +, K +, Pb 2+ ionophore. Most commonly it is an antiporter of H + and K +. In the past nigericin was used as an antibiotic active against gram positive bacteria. … sonic chaos revolutionWeb25 sep. 2024 · Human African trypanosomiasis (HAT) is caused by Trypanosoma brucei parasites. The T. brucei aquaglyceroporin isoform 2, TbAQP2, has been linked to the uptake of pentamidine. Negative membrane potentials and transmembrane pH gradients were suggested to promote transport of the dicationic antitrypanosomal drug. Application of … sonic character mightyWebNigericin (NSC 292567) sodium salt is an antibiotic derived from Streptomyces hygroscopicus that works by acting as an H+, K+, and Pb2+ ionophore .Nigericin can activate NLRP3 inflammasome to induce pro-inflammatory and immunostimulatory processes. CAS No. 28643-80-3 Selleck's Nigericin (NSC 292567) sodium salt has … small homemade carrot cakeWebAbstract Ionophore antibiotics are compounds produced by microorganisms (mainly spore-forming bacteria) ; they act by specifically increasing the ion permeability of the cell membrane. In Vol. sonic chao wallpaperWebIn summary care must be taken when using the putative K+/H+ ionophore nigericin as an experimental tool in synaptosomes, as under standard conditions (i.e. in the presence of high external Na+) nigericin behaves as a Na+/H+ ionophore. Publication types Research Support, Non-U.S. Gov't MeSH terms Animals sonic chaotix game