WebAug 13, 2007 · Other experiments suggested that reduced expression of Cdx2 is important in colon tumorigenesis through the mTOR pathway. Savory et al. (2009) found that knockin mice in which Cdx2 replaced Cdx1 were viable and fertile, with the mutant allele transmitted at a mendelian frequency. The mutant mice had no overt skeletal abnormalities and no ... WebSep 17, 2012 · Among them, the Cdx2 homeotic gene is essential during development 1 and homeostasis, 2, 3 as it controls the organization of the stem cell niche, provides intestinal identity to stem cells and...
Cdx2 caudal type homeobox 2 [ (house mouse)] - National Center …
WebApr 1, 2024 · CDX2 is essential for maintaining the polarity of TE cells via regulation of PKCɑ expression. (A) Immunostaining of F-actin in D6.5 siCDX2 (n=12) and siControl … WebThe transcription factor, Cdx2, plays an important role in the regulation of intestinal epithelial differentiation. Forced expression of the Cdx2 gene in undifferentiated intestinal crypt cells induces the development of a differentiated phenotype. The current study was designed to determine changes in differentiated intestinal epithelial cell ... christmas at thorpe park
Immunoexpression of CDX2 in metastatic nonintestinal …
WebOct 29, 2012 · Challenging the prevailing view (based largely on mouse models of cancer) that CDX2 is a tumor-suppressor gene in colorectal cancer (1, 2), we demonstrated through extensive functional studies of cultured colorectal cancer cells that amplified CDX2 is an oncogene. Moreover, in colorectal cancers with CDX2 amplification, the cancer cells … WebMay 26, 2024 · e15115. Background: CDX2 (Caudal Type Homeobox 2), a nuclear protein, is essential for the proliferation and development of intestinal epithelial cells and is … WebMar 21, 2024 · CDX2 (Caudal Type Homeobox 2) is a Protein Coding gene. Diseases associated with CDX2 include Sirenomelia and Pseudomyxoma Peritonei.Among its … christmas at the willard hotel